Cuminaldehyde → (2-Benzyloxyphenyl)-(4-isopropylphenyl)methanol

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Reaction Steps

In a nitrogen stream, an n-butyllithium hexane solution (2.44 M, 5.14 mL) was added dropwise to a solution of 1-benzyloxy-2-bromobenzene (3.0 g, 11.4 mmol) in THF (114 mL) at −78° C. and the reaction mixture was stirred at the same temperature for 30 minutes. To this solution, a solution of 4-isopropylbenzaldehyde (1.41 g, 9.49 mmol) in THF (38 mL) was added dropwise at −78° C. The reaction mixture was stirred at the same temperature for one hour and furthermore at 0° C. for one hour. Water was added thereto and the mixture was extracted with ethyl acetate. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)] to obtain the title compound (2.63 g, 84%).

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