Hydrochloric Acid → 2-(4-Isopropylbenzyl)phenol

Participants

Reaction Steps

To a solution of (2-benzyloxyphenyl)-(4-isopropylphenyl)methanol (2.63 g, 7.92 mmol) in methanol (50 mL), a 20% palladium hydroxide catalyst (263 mg) was added and furthermore 2N—HCl (0.4 mL) was added thereto, and the mixture solution was stirred under a hydrogen atmosphere for 15 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:4)] to obtain the title compound (1.31 g, 73%).

Provenance & Evidence