Water → HCID 67459549, compound

Participants

Reaction Conditions

Reaction Steps

In a nitrogen stream, triethylsilane (0.73 mL, 4.6 mmol) and a boron trifluoride-diethyl ether complex (0.5 mL, 4.0 mmol) were added to a solution of (2-benzyloxyphenyl)-(4-cyclopropylphenyl)methanol (1.3 g, 4.0 mmol) in acetonitrile (7 mL) at −40° C. and the mixture solution was stirred at the same temperature for 1.5 hours and furthermore at 0° C. for 30 minutes. Water was added thereto and the mixture was extracted with methylene chloride. The organic layer was washed with a saturated sodium chloride aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:7)] to obtain the title compound (1.2 g, 95%).

Provenance & Evidence