Hydrochloric Acid → HCID 23072753, compound

Participants

Reaction Steps

To a solution of (2-benzyloxyphenyl)-(4-trifluoromethylphenyl)-methanol (2.46 g, 6.85 mmol) in methanol (68.5 mL), a 20% palladium hydroxide catalyst (246 mg) was added and furthermore 36% HCl (0.59 mL) was added thereto, and the mixture solution was stirred under a hydrogen atmosphere for 3.5 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:8)] to obtain the title compound (1.49 g, 86%).

Provenance & Evidence