Hydrochloric Acid → HCID 67459068, compound

Participants

Reaction Steps

To a solution of (2-benzyloxy-4-fluorophenyl)-(4-methoxyphenyl)-methanol (2.095 g, 6.19 mmol) in methanol (20 mL), a 20% palladium hydroxide catalyst (200 mg) was added and furthermore 2N—HCl (0.3 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere for 16 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure, and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)] to obtain the title compound (489 mg, 34%).

Provenance & Evidence