Hydrochloric Acid → HCID 67458585, compound

Participants

Reaction Steps

To a (2-benzyloxyphenyl)-(3-fluoro-4-methoxyphenyl)-methanol (1.50 g, 4.43 mmol) methanol solution (29 mL), a 20% palladium hydroxide catalyst (150 mg) was added, and furthermore 2N—HCl (2 mL) was added thereto. The mixture was stirred under a hydrogen atmosphere for 15 hours, and then the catalyst was filtered off. The solvent was distilled under reduced pressure and the obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:5)] to obtain the title compound (0.95 g, 92%).

Provenance & Evidence