Triphenylphosphine → HCID 67460302, compound

Participants

Reaction Steps

In a nitrogen stream, diisopropylazodicarboxylate (0.14 mL, 0.72 mmol) was slowly added dropwise to a mixture of (4-cyclopropylphenyl)-(3-hydroxypyridin-4-yl)methanone (0.18 g, 0.74 mmol), (1S,2S,3S,4R,5R)-2,3,4-trisbenzyloxy-5-benzyloxymethylcyclohexanol (0.20 g, 0.37 mmol), triphenylphosphine (0.19 g, 0.74 mmol) and toluene (1.3 mL) under cooling with ice. The reaction mixture was stirred at room temperature for three hours, and then the solvent was distilled under reduced pressure and the obtained residue was purified by silica gel flash column chromatography [developing solution=n-hexane:ethyl acetate (2:3)] to obtain the title product (0.20 g, 71%).

Provenance & Evidence