Ethyl Acetate → HCID 67461471, compound

Participants

Reaction Steps

In a nitrogen stream, zinc (0.14 g, 2.14 mmol) was added to a solution of 4-[chloro-(4-cyclopropylphenyl)-methyl]-3-((1R,2S,3S,4R,5R)-2,3,4-trisbenzyloxy-5-benzyloxymethyl-cyclohexyloxy)pyridine (0.22 g, 0.28 mmol) in methylene chloride (4.1 mL) and acetic acid (12.4 mL), and the mixture solution was stirred at room temperature for 14 hours. To the reaction mixture was added ethyl acetate and the mixture was washed with a saturated hydrogencarbonate aqueous solution and dried (anhydrous magnesium sulfate), and then the solvent was distilled under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=ethyl acetate:n-hexane (1:1)] to obtain the title product (0.14 g, 67%).

Provenance & Evidence