Methanol → HCID 67458030, compound

Participants

Reaction Steps

Triethylsilane (2.7 mL, 16.9 mmol) and a boron trifluoride-diethyl ether complex (1.2 mL, 9.47 mmol) were added to a solution of (3-bromo-4-ethoxyphenyl)-(4-ethylphenyl)methanol (2.83 g, 8.44 mmol) in methylene chloride (20 mL) at 0° C. and the mixture was stirred for three hours. Methanol (50%)-water (4 mL) was added to the reaction mixture and the resulting mixture was extracted with methylene chloride. The extract was washed with a saturated sodium chloride aqueous solution, and then dried over magnesium sulfate. The residue obtained by distilling the solvent under reduced pressure was purified by silica gel column chromatography {developing solution=n-hexane to n-hexane-ethyl acetate [4% (v/v)]} to obtain the title compound (2.69 g, 100%).

Provenance & Evidence