HCID 67460491, compound → HCID 11553111, compound

Participants

Reaction Steps

To a solution of the (1S,2R,3S,4R,5R)-2,3,4-tris-benzyloxy-5-benzyloxymethyl-1-[2-ethoxy-5-(4-ethylbenzyl)-phenyl]cyclohexanol (402 mg, 0.517 mmol) in THF (4 ml) and methanol (2 mL) as obtained in Example 67, a 20% palladium hydroxide catalyst (78 mg) was added and the mixture solution was stirred under a hydrogen atmosphere for 19 hours. After filtering the catalyst, the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography [developing solution=methylene chloride:methanol (10:1)] to obtain the title compound (42 mg, 20%).

Provenance & Evidence