Ethanol → Ethyl 2-(5-bromopyridin-3-yl)acetate

HRID 554578Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[N:6][CH:7]=1.S(=O)(=O)(O)O.[CH3:17][CH2:18]O>>[CH2:17]([O:10][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[N:6][CH:7]=[C:2]([Br:1])[CH:3]=1)[CH3:18]

Participants

Reactant 3

HCID 702Ethanol

HCID 1118Sulfuric Acid

HCID 28025392-(5-Bromopyridin-3-yl)acetic acid

Product 1

HCID 54116619Ethyl 2-(5-bromopyridin-3-yl)acetate

Procedure

5-Bromo-3-pyridylacetic acid was treated with 5% concentrated sulfuric acid in EtOH at reflux overnight to give (5-bromo-pyridin-3-yl)-acetic acid ethyl ester.

Workup

temperatureat reflux overnight

Sources & evidence

ORD record: ord-e8252667944846888dfb4cc64d24b682
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08049015B2

Reaction notes

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