HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(5-bromopyridin-3-yl)acetate → (5-{4-benzylcarbamoyl-2-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-phenyl}-pyridin-3-yl)-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(5-bromopyridin-3-yl)acetate | HCID 54116619 | — |
| Reactant | N-Benzyl-3-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide | HCID 67212540 | — |
| Product | (5-{4-benzylcarbamoyl-2-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-phenyl}-pyridin-3-yl)-acetic acid ethyl ester | HCID 67212484 | — |
Reaction Steps
N-Benzyl-3-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide and (5-bromo-pyridin-3-yl)-acetic acid ethyl ester were reacted as described in Example 3, Step 6 to provide (5-{4-benzylcarbamoyl-2-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-phenyl}-pyridin-3-yl)-acetic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049015B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-d322498a59a74271a5cdd9ed9262ebf6 |
| Source note | uspto-grants-2011_11 |