Ethyl 2-(5-bromopyridin-3-yl)acetate → HCID 67212481, compound

HRID 554602Notes

Reaction equation

HRID 554602 reaction equation
[CH2:1]([N:8]([CH2:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][C:24]=1B1OC(C)(C)C(C)(C)O1)[C:18]([NH:20][CH3:21])=[O:19])[C:9]([CH:11]1[CH2:13][CH2:12]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:34]([O:36][C:37](=[O:46])[CH2:38][C:39]1[CH:40]=[N:41][CH:42]=[C:43](Br)[CH:44]=1)[CH3:35]>>[CH2:34]([O:36][C:37](=[O:46])[CH2:38][C:39]1[CH:40]=[N:41][CH:42]=[C:43]([C:24]2[CH:23]=[CH:22][C:17]([C:18](=[O:19])[NH:20][CH3:21])=[CH:16][C:15]=2[CH2:14][N:8]([CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[C:9]([CH:11]2[CH2:13][CH2:12]2)=[O:10])[CH:44]=1)[CH3:35]

Participants

3

Reactant 2

HCID 54116619Ethyl 2-(5-bromopyridin-3-yl)acetateHCID 67212622HCID 67212622, compound

Product 1

HCID 67212481HCID 67212481, compound

Procedure

3-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-N-methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide and (5-bromo-pyridin-3-yl)-acetic acid ethyl ester were reacted as described in Example 3, Step 6 to provide (5-{2-[(N-benzyl-N-cyclopropanecarbonyl-amino)-methyl]-4-methylcarbamoyl-phenyl}-pyridin-3-yl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-c22d2f39c1e64520a76ac230eef3f28d
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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