HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl ester → [2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl ester | HCID 58565158 | — |
| Reactant | 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)benzaldehyde | HCID 86640534 | — |
| Product | [2-Chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester | HCID 86640533 | — |
Reaction Steps
(5-Bromo-2-chloro-pyridin-3-yl)-acetic acid ethyl ester and 2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzaldehyde were reacted as described in Example 3, Step 6 to provide [2-chloro-5-(2-formyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049015B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-d0b8f0014d9e49b7b9e4951423b6ae32 |
| Source note | uspto-grants-2011_11 |