Cyclopropanecarboxylic acid → HCID 86640536, compound

HRID 554612Notes

Reaction equation

HRID 554612 reaction equation
[CH2:1]([O:3][C:4](=[O:27])[CH2:5][C:6]1[C:7]([Cl:26])=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:11]=1)[CH3:2].[CH:28]1([C:31](O)=[O:32])[CH2:30][CH2:29]1>>[CH2:1]([O:3][C:4](=[O:27])[CH2:5][C:6]1[C:7]([Cl:26])=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:20])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([C:31]([CH:28]2[CH2:30][CH2:29]2)=[O:32])[CH2:24][CH3:25])[CH:11]=1)[CH3:2]

Participants

3

Reactant 2

HCID 15655Cyclopropanecarboxylic acidHCID 86640535[2-Chloro-5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Product 1

HCID 86640536HCID 86640536, compound

Procedure

[2-Chloro-5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester and cyclopropanecarboxylic acid were reacted as described in Example 8, Step 6 to provide (2-chloro-5-{2-[(N-cyclopropanecarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-826fbf73d02347bfaf209d3e964e9e66
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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