Cyclopropanecarboxylic acid → Cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide

HRID 554616Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:11]=2[CH2:12][NH:13][CH2:14][CH3:15])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1.[CH:24]1([C:27]([OH:29])=O)[CH2:26][CH2:25]1>>[Br:1][C:2]1[CH:3]=[C:4]([C:10]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:21])[F:22])=[CH:16][C:11]=2[CH2:12][N:13]([CH2:14][CH3:15])[C:27]([CH:24]2[CH2:26][CH2:25]2)=[O:29])[C:5]([O:8][CH3:9])=[N:6][CH:7]=1

Participants

Reactant 2

HCID 15655Cyclopropanecarboxylic acid

HCID 67212358[2-(5-Bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amine

Product 1

HCID 67212469Cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide

Procedure

[2-(5-Bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amine and cyclopropanecarboxylic acid were reacted as described in Example 8, Step 6 to provide cyclopropanecarboxylic acid [2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-ethyl-amide.

Sources & evidence

ORD record: ord-0202424bd03546eb94012778efae2e02
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08049015B2

Reaction notes

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