HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl isocyanate → {5-[2-(3-Benzyl-1-ethyl-ureidomethyl)-4-trifluoromethyl-phenyl]-pyridin-3-yl}-acetic acid methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl isocyanate | HCID 76639 | — |
| Reactant | HCID 131729246 | HCID 131729246 | — |
| Product | {5-[2-(3-Benzyl-1-ethyl-ureidomethyl)-4-trifluoromethyl-phenyl]-pyridin-3-yl}-acetic acid methyl ester | HCID 67460349 | — |
Reaction Steps
[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid methyl ester, dihydrochloride and benzyl isocyanate were reacted as described in Example 2, Step 3, to provide {5-[2-(3-benzyl-1-ethyl-ureidomethyl)-4-trifluoromethyl-phenyl]-pyridin-3-yl}-acetic acid methyl ester. The ester was hydrolyzed to the acid as described in Example 12, Step 4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049015B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-f0757183dc6b43e8b889d6e60c41b7fd |
| Source note | uspto-grants-2011_11 |