Ethyl 2-(5-bromopyridin-3-yl)acetate → HCID 67212500, compound

HRID 554641Notes

Reaction equation

HRID 554641 reaction equation
[C:1]([O:5][C:6](=[O:30])[N:7]([CH2:28][CH3:29])[CH2:8][C:9]1[CH:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[CH:12]=[CH:11][C:10]=1B1OC(C)(C)C(C)(C)O1)([CH3:4])([CH3:3])[CH3:2].[CH2:31]([O:33][C:34](=[O:43])[CH2:35][C:36]1[CH:37]=[N:38][CH:39]=[C:40](Br)[CH:41]=1)[CH3:32]>>[CH2:31]([O:33][C:34](=[O:43])[CH2:35][C:36]1[CH:37]=[N:38][CH:39]=[C:40]([C:10]2[CH:11]=[CH:12][C:13]([C:15]([F:16])([F:17])[F:18])=[CH:14][C:9]=2[CH2:8][N:7]([C:6]([O:5][C:1]([CH3:3])([CH3:4])[CH3:2])=[O:30])[CH2:28][CH3:29])[CH:41]=1)[CH3:32]

Participants

3

Reactant 2

HCID 54116619Ethyl 2-(5-bromopyridin-3-yl)acetateHCID 67212456Ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid tert-butyl ester

Product 1

HCID 67212500HCID 67212500, compound

Procedure

Ethyl-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-carbamic acid tert-butyl ester and (5-bromo-pyridin-3-yl)-acetic acid ethyl ester were reacted as described in Example 8, Step 4 to provide (5-{2-[(N-tert-butoxycarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-pyridin-3-yl)-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-6802e27aaef44c95a8d59e4ceb4900ab
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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