Acetyl chloride → N-benzyl-N-[2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-acetamide

HRID 554644Notes

Reaction equation

HRID 554644 reaction equation
[CH2:1]([NH:8][CH2:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[CH:13]=[CH:12][C:11]=1[C:20]1[C:21]([O:27][CH3:28])=[N:22][CH:23]=[C:24]([Br:26])[CH:25]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:29](Cl)(=[O:31])[CH3:30]>>[CH2:1]([N:8]([CH2:9][C:10]1[CH:15]=[C:14]([C:16]([F:19])([F:17])[F:18])[CH:13]=[CH:12][C:11]=1[C:20]1[C:21]([O:27][CH3:28])=[N:22][CH:23]=[C:24]([Br:26])[CH:25]=1)[C:29](=[O:31])[CH3:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6367Acetyl chlorideHCID 67212914Benzyl-[2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-amine

Product 1

HCID 67212466N-benzyl-N-[2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-acetamide

Procedure

Benzyl-[2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-amine and acetyl chloride were reacted as described in Example 11, Step 2 to provide N-benzyl-N-[2-(5-bromo-2-methoxy-pyridin-3-yl)-5-trifluoromethyl-benzyl]-acetamide.

Sources & evidence

ORD record
ord-5e6b46ae9de6443a9702f9c5f16916fa
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

Loading…