HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 554650Generated: October 30, 2026
Azobisisobutyronitrile → 3-Bromo-5-(dibromomethyl)-2-methoxypyridine
https://huagongshe.com/reaction/554650
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Azobisisobutyronitrile | HCID 6547 | — |
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 3-Bromo-5-bromomethyl-2-methoxy-pyridine | HCID 58539510 | — |
| Solvent | Benzene | HCID 241 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-Bromo-5-(dibromomethyl)-2-methoxypyridine | HCID 58539673 | — |
Reaction Steps
3-Bromo-5-bromomethyl-2-methoxy-pyridine (6.03 g, 21.5 mmol), N-bromosuccinimide (4.09 g, 23.0 mmol), and azobisisobutyronitrile (one scoop) were combined in benzene (40 mL) and stirred at 80° C. for 4 hours. After cooling, the mixture was diluted with H2O and extracted with EtOAc. The combined organic layers were dried over MgSO4, filtered, and concentrated to give 3-Bromo-5-dibromomethyl-2-methoxy-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08049015B2 |
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| Source dataset | uspto-grants-2011_11 |
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| ORD ID | ord-6f8bc6f6d6664cdab0b03c3ab78eda13 |
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| Source note | uspto-grants-2011_11 |
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