HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 3-Bromo-5-bromomethyl-2-methoxy-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 58539347 | HCID 58539347 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 3-Bromo-5-bromomethyl-2-methoxy-pyridine | HCID 58539510 | — |
Reaction Steps
To (5-bromo-6-methoxy-pyridin-3-yl)-methanol (2.86 g, 13.1 mmol) in DME (30 mL) was added phosphorus tribromide (1.9 mL, 19.7 mmol), and the reaction was stirred for 15 minutes. The mixture was worked up with EtOAc and saturated aqueous NaHCO3, and the combined organic layers were dried over MgSO4, filtered, and concentrated to give 3-bromo-5-bromomethyl-2-methoxy-pyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049015B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-9c368060408646bdb5a73561c3db981c |
| Source note | uspto-grants-2011_11 |