HRID554657

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID58539686

Ethyl 5-bromo-6-methoxy-3-pyridineacetate

C10H12BrNO3

结构：CCN(Cc1cc(C(F)(F)F)ccc1B1OC(C)(C)C(C)(C)O1)C(=O)NCc1ccccc1

HCID66607126

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)Cc1cnc(OC)c(-c2ccc(C(F)(F)F)cc2CN(CC)C(=O)NCc2ccccc2)c1

HCID67459164

未命名化合物

PROCEDURE

实验过程

3-Benzyl-1-ethyl-1-[2-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-5-trifluoromethyl-benzyl]-urea and (5-bromo-6-methoxy-pyridin-3-yl)-acetic acid ethyl ester were reacted as described in Example 11, Step 4 to provide {5-[2-(3-benzyl-1-ethyl-ureidomethyl)-4-trifluoromethyl-phenyl]-6-methoxy-pyridin-3-yl}-acetic acid ethyl ester.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-582496d275f14e2995b050662fdee406
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08049015B2
来源说明: uspto-grants-2011_11

反应 SMILES

[CH2:1]([NH:8][C:9](=[O:33])[N:10]([CH2:31][CH3:32])[CH2:11][C:12]1[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][C:13]=1B1OC(C)(C)C(C)(C)O1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:34]([O:36][C:37](=[O:48])[CH2:38][C:39]1[CH:40]=[N:41][C:42]([O:46][CH3:47])=[C:43](Br)[CH:44]=1)[CH3:35]>>[CH2:34]([O:36][C:37](=[O:48])[CH2:38][C:39]1[CH:40]=[N:41][C:42]([O:46][CH3:47])=[C:43]([C:13]2[CH:14]=[CH:15][C:16]([C:18]([F:19])([F:20])[F:21])=[CH:17][C:12]=2[CH2:11][N:10]([CH2:31][CH3:32])[C:9]([NH:8][CH2:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[O:33])[CH:44]=1)[CH3:35]