2,6-Dimethoxypyrimidine-4-carboxylic acid → HCID 67212545, compound

HRID 554661Notes

Reaction equation

HRID 554661 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[CH:13]=1)[CH3:4].[CH3:29][O:30][C:31]1[N:36]=[C:35]([O:37][CH3:38])[CH:34]=[C:33]([C:39](O)=[O:40])[N:32]=1>>[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:23])[F:22])=[CH:16][C:15]=2[CH2:24][N:25]([C:39]([C:33]2[CH:34]=[C:35]([O:37][CH3:38])[N:36]=[C:31]([O:30][CH3:29])[N:32]=2)=[O:40])[CH2:26][CH3:27])[CH:13]=1)[CH3:4]

Participants

3

Reactant 2

HCID 27362102,6-Dimethoxypyrimidine-4-carboxylic acidHCID 131729247[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride

Product 1

HCID 67212545HCID 67212545, compound

Procedure

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride and 2,4-dimethoxypyrimidine-6-carboxylic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-(2,6-dimethoxy-pyrimidine-4-carbonyl)-N-ethyl-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester. The ester was hydrolyzed to the acid as described in Example 8, Step 7.

Sources & evidence

ORD record
ord-d0c95b15322e4090974c174a729cca33
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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