2-(6-Chloropyridin-3-yl)acetic acid → HCID 86640543, compound

HRID 554662Notes

Reaction equation

HRID 554662 reaction equation
Cl.Cl.[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:23])([F:22])[F:21])=[CH:16][C:15]=2[CH2:24][NH:25][CH2:26][CH3:27])[CH:13]=1)[CH3:4].[Cl:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37](O)=[O:38])=[CH:32][N:31]=1>>[CH2:3]([O:5][C:6](=[O:28])[CH2:7][C:8]1[CH:9]=[N:10][CH:11]=[C:12]([C:14]2[CH:19]=[CH:18][C:17]([C:20]([F:21])([F:23])[F:22])=[CH:16][C:15]=2[CH2:24][N:25]([C:37](=[O:38])[CH2:36][C:33]2[CH:32]=[N:31][C:30]([Cl:29])=[CH:35][CH:34]=2)[CH2:26][CH3:27])[CH:13]=1)[CH3:4]

Participants

3

Reactant 2

HCID 140715712-(6-Chloropyridin-3-yl)acetic acidHCID 131729247HCID 131729247, compound

Product 1

HCID 86640543HCID 86640543, compound

Procedure

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester, dihydrochloride and 2-chloropyridine-5-acetic acid were reacted as described in Example 8, Step 6 to provide {5-[2-({N-[2-(6-chloro-pyridin-3-yl)-acetyl]-N-ethyl-amino}-methyl)-4-trifluoromethyl-phenyl]-pyridin-3-yl}-acetic acid ethyl ester.

Sources & evidence

ORD record
ord-2c93c19e9f464e0db287b14ff34aaeba
Source dataset
uspto-grants-2011_11
Patent number
US08049015B2

Reaction notes

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