Ethoxyacetic acid → [5-(2-{[N-(2-ethoxy-acetyl)-N-ethyl-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

Participants

Role	Name	HCID	Charge
Reactant	Ethoxyacetic acid	HCID 12301	—
Reactant	[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester	HCID 67212445	—
Product	[5-(2-{[N-(2-ethoxy-acetyl)-N-ethyl-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester	HCID 67212482	—

Reaction Steps

[5-(2-ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester and ethoxyacetic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-(2-ethoxy-acetyl)-N-ethyl-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester. The ester was hydrolyzed to the acid as described in Example 30, Step 2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049015B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-0e6d5751783c45b6a072bb8b14dbd752
Source note	uspto-grants-2011_11