3-(Pyridin-3-yl)propanoic acid → HCID 67213040、化合物

HRID 554670ノート

反応式

HRID 554670 の反応式
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:11]=1)[CH3:2].[N:27]1[CH:32]=[CH:31][CH:30]=[C:29]([CH2:33][CH2:34][C:35]([OH:37])=O)[CH:28]=1>>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:7]=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([CH2:24][CH3:25])[C:35](=[O:37])[CH2:34][CH2:33][C:29]2[CH:28]=[N:27][CH:32]=[CH:31][CH:30]=2)[CH:11]=1)[CH3:2]

参加物

3

反応物 2

HCID 2596243-(Pyridin-3-yl)propanoic acidHCID 67212445[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester

生成物 1

HCID 67213040HCID 67213040、化合物

実験手順

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester and 3-pyridinepropionic acid were reacted as described in Example 8, Step 6 to provide [5-(2-{[N-ethyl-N-(3-pyridin-3-yl-propionyl)-amino]-methyl}-4-trifluoromethyl-phenyl)-pyridin-3-yl]-acetic acid ethyl ester. The ester was hydrolyzed to the acid as described in Example 30, Step 2.

出典と根拠

ORDレコード
ord-e26f394fb64e4b678e4e5376fb580519
出典データセット
uspto-grants-2011_11
特許番号
US08049015B2

反応ノート

読み込み中…