Ethyl chloroformate → HCID 67212331, compound

HRID 554677Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[N:8][C:9]([O:26][CH3:27])=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH2:22][NH:23][CH2:24][CH3:25])[CH:11]=1)[CH3:2].Cl[C:30]([O:32][CH2:33][CH3:34])=[O:31]>>[CH2:1]([O:3][C:4](=[O:28])[CH2:5][C:6]1[CH:7]=[N:8][C:9]([O:26][CH3:27])=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:20])([F:19])[F:21])=[CH:14][C:13]=2[CH2:22][N:23]([C:30]([O:32][CH2:33][CH3:34])=[O:31])[CH2:24][CH3:25])[CH:11]=1)[CH3:2]

Participants

Reactant 2

HCID 10928Ethyl chloroformate

HCID 67212646HCID 67212646, compound

Product 1

HCID 67212331HCID 67212331, compound

Procedure

[5-(2-Ethylaminomethyl-4-trifluoromethyl-phenyl)-6-methoxy-pyridin-3-yl]-acetic acid ethyl ester and ethyl chloroformate were reacted as described in Example 5, Step 4 to provide (5-{2-[(N-ethoxycarbonyl-N-ethyl-amino)-methyl]-4-trifluoromethyl-phenyl}-6-methoxy-pyridin-3-yl)-acetic acid ethyl ester. The ester was hydrolyzed to the acid as described in Example 3, Step 7.

Sources & evidence

ORD record: ord-943f1a30888341d1afd396c77bd8d399
Source dataset: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08049015B2

Reaction notes

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