HCID 66782132, compound → HCID 66781742, compound

HRID 554737Notes

Reaction equation

HRID 554737 reaction equation
C(OC(=O)[NH:10][CH:11]([C:24](=[O:44])[N:25]([CH2:34][C:35]1[C:40]2[N:41]=[CH:42][S:43][C:39]=2[CH:38]=[CH:37][CH:36]=1)[CH2:26][CH:27]([O:31][CH2:32][CH3:33])[O:28][CH2:29][CH3:30])[CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[CH:15][CH:14]=1)C1C=CC=CC=1>CO.[Pd]>[NH2:10][CH:11]([CH2:12][C:13]1[CH:14]=[CH:15][C:16]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[CH:17][CH:18]=1)[C:24]([N:25]([CH2:34][C:35]1[C:40]2[N:41]=[CH:42][S:43][C:39]=2[CH:38]=[CH:37][CH:36]=1)[CH2:26][CH:27]([O:31][CH2:32][CH3:33])[O:28][CH2:29][CH3:30])=[O:44]

Participants

4

Reactant 1

HCID 66782132HCID 66782132, compound

Product 1

HCID 66781742HCID 66781742, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a solution of [1-[Benzothiazol-4-ylmethyl-(2,2-diethoxy-ethyl)-carbamoyl]-2-(4-tert-butoxy-phenyl)-ethyl]-carbamic acid benzyl ester (3.64 g, 5.76 mmol) in MeOH (50 mL) was added Pd/C (500 mg). After 2 h of stirring under H2 atmosphere, the solution was filtered on Celite and the solvent was evaporated to afford 2-Amino-N-benzothiazol-4-ylmethyl-3-(4-tert-butoxy-phenyl)-N-(2,2-diethoxy-ethyl)-propionamide, which was used next step without further purification.

Workup

  1. filtrationthe solution was filtered on Celite
  2. customthe solvent was evaporated

Sources & evidence

ORD record
ord-79a94f5c518c4295841b39fc5f74a8c6
Source dataset
uspto-grants-2011_11
Patent number
US08049008B2

Reaction notes

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