反应详情

To fuming nitric acid (200 ml), 1-(4-bromophenyl)-1-propanone (40 g) was added while keeping the inside temperature of the mixture at 5 to 10° C. The reaction solution was stirred at that temperature for 30 minutes and then poured into ice. The precipitate was collected by filtration, washed with distilled water, and recrystallized from methanol to obtain the title compound (18 g).

1. customat 5 to 10° C
2. additionpoured into ice
3. filtrationThe precipitate was collected by filtration
4. washwashed with distilled water
5. customrecrystallized from methanol