HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chlorobenzenesulfonyl chloride → tert-butyl (2R)-2-{[(4-chloro-2-nitrophenyl)sulfonyl]amino}butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chlorobenzenesulfonyl chloride | HCID 7398 | — |
| Reactant | 4-Chloro-2-nitrophenylsulfonyl chloride | HCID 20631 | — |
| Reactant | tert-Butyl alaninate hydrochloride | HCID 11275390 | — |
| Product | tert-butyl (2R)-2-{[(4-chloro-2-nitrophenyl)sulfonyl]amino}butanoate | HCID 66935149 | — |
Reaction Steps
Instead of the starting material compound of Reference Example 166, that is, L-alanine tert-butyl ester hydrochloride, D-2-amino-n-butyric acid tert-butyl ester hydrochloride was used, further, instead of 4-chlorobenzenesulfonyl chloride, 4-chloro-2-nitrobenzenesulfonyl chloride was used for the similar procedure as with Reference Example 167 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049006B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-bdebd218093e4411a1b8438629a1a95e |
| Source note | uspto-grants-2011_11 |