HuagongsheHuagongshe Chemistry Print Report · For research reference only
Aniline → N-[(1R)-2-anilino-1-methyl-2-oxoethyl]-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Aniline | HCID 6115 | — |
| Reactant | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| Reactant | Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate | HCID 76588771 | — |
| Product | N-[(1R)-2-anilino-1-methyl-2-oxoethyl]-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide | HCID 57671048 | — |
Reaction Steps
Instead of the starting material of Example 220, that is, the compound 119, the compound 100 was used, while instead of the glycine tert-butyl ester hydrochloride, aniline was used for the similar procedure as in Example 220 to obtain the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08049006B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-0c1535f2cebe490ea1ca2562f7d468a6 |
| Source note | uspto-grants-2011_11 |