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2-Aminopyridine → 6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-n-{(1r)-1-[(2-pyridylamino)carbonyl]propyl}-1,4-diazepan-1-carboxamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminopyridine | HCID 10439 | — |
| 反応物 | Glycine tert-butyl ester hydrochloride | HCID 2725036 | — |
| 反応物 | Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate | HCID 76588771 | — |
| 生成物 | 6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-n-{(1r)-1-[(2-pyridylamino)carbonyl]propyl}-1,4-diazepan-1-carboxamide | HCID 57671142 | — |
反応手順
Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, 2-aminopyridine was used for the similar procedure as in Example 220 to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08049006B2 |
| 出典データセット | uspto-grants-2011_11 |
| ORD ID | ord-a0055453a1a64e6d87578aa860231b7c |
| 出典メモ | uspto-grants-2011_11 |