Glycine tert-butyl ester hydrochloride → N-{(1R)-1-[(tert-butoxyamino)carbonyl]propyl}-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide

Participants

Role	Name	HCID	Charge
Reactant	Glycine tert-butyl ester hydrochloride	HCID 2725036	—
Reactant	Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate	HCID 76588771	—
Product	N-{(1R)-1-[(tert-butoxyamino)carbonyl]propyl}-6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-carboxamide	HCID 57671032	—

Reaction Steps

Instead of the starting material compound of Example 220, that is, glycine tert-butyl ester hydrochloride, O-(tert-butyl)hydroxylaminehydrochloride was used for the similar procedure as in Example 220 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049006B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-c9be101665be45eca9421a4bc079276f
Source note	uspto-grants-2011_11