Glycine tert-butyl ester hydrochloride → (2r)-2-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}propanoic acid

Participants

Role	Name	HCID	Charge
Reactant	Glycine tert-butyl ester hydrochloride	HCID 2725036	—
Reactant	D-Alanine tert-butyl ester hydrochloride	HCID 16211919	—
Reactant	Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate	HCID 76588771	—
Product	(2r)-2-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}propanoic acid	HCID 57670992	—

Reaction Steps

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, D-alanine tert-butyl ester hydrochloride was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049006B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-1c8f15c1258840c092bc109114da3a39
Source note	uspto-grants-2011_11