HRID554799

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2725036

tert-Butyl glycinate--hydrogen chloride (1/1)

C6H14ClNO2

HCID2737408

tert-Butyl-3-aminobenzoate

C11H15NO2

结构：CCC(NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)NCC(=O)OC(C)(C)C

HCID76588771

未命名化合物

PRODUCTS

生成物

结构：CC[C@@H](NC(=O)N1CC(=O)NCC(Cc2cc(Cl)ccc2OC)C1=O)C(=O)Nc1cccc(C(=O)O)c1

HCID57671161

未命名化合物

PROCEDURE

实验过程

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, tert-butyl 3-aminobenzoate was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3847189dd9fc404cbc020cb55d2510a2
来源数据集: uspto-grants-2011_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08049006B2
来源说明: uspto-grants-2011_11

反应 SMILES

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22]CC(OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.N[C:48]1[CH:49]=[C:50]([CH:58]=[CH:59][CH:60]=1)[C:51]([O:53]C(C)(C)C)=[O:52]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C:48]2[CH:49]=[C:50]([CH:58]=[CH:59][CH:60]=2)[C:51]([OH:53])=[O:52])=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1