Benzoic acid, 4-amino-, 1,1-dimethylethyl ester → HCID 57671167, compound

HRID 554805Notes

Reaction equation

HRID 554805 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][CH:19]([CH2:31][CH3:32])[C:20]([NH:22]CC(OC(C)(C)C)=O)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1.Cl.C(OC(=O)CN)(C)(C)C.N[C:48]1[CH:60]=[CH:59][C:51]([C:52]([O:54]C(C)(C)C)=[O:53])=[CH:50][CH:49]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:35][CH3:36])=[C:6]([CH:34]=1)[CH2:7][CH:8]1[C:14](=[O:15])[N:13]([C:16]([NH:18][C@H:19]([CH2:31][CH3:32])[C:20]([NH:22][C:48]2[CH:60]=[CH:59][C:51]([C:52]([OH:54])=[O:53])=[CH:50][CH:49]=2)=[O:21])=[O:17])[CH2:12][C:11](=[O:33])[NH:10][CH2:9]1

Participants

4

Reactant 3

HCID 233272Benzoic acid, 4-amino-, 1,1-dimethylethyl esterHCID 2725036Glycine tert-butyl ester hydrochlorideHCID 76588771Tert-butyl {[2-({[6-(5-chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}acetate

Product 1

HCID 57671167HCID 57671167, compound

Procedure

Instead of the starting material compound of Example 220, that is, the glycine tert-butyl ester hydrochloride, tert-butyl 4-aminobenzoate was used for the similar procedure as in Example 220 and Example 245 to obtain the title compound.

Sources & evidence

ORD record
ord-66c04bcd75294201a3f661ed271cf7a2
Source dataset
uspto-grants-2011_11
Patent number
US08049006B2

Reaction notes

Loading…