4-Fluoro-3-nitrobenzoic acid → 3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-fluorobenzoic acid

Participants

Role	Name	HCID	Charge
Reactant	4-Fluoro-3-nitrobenzoic acid	HCID 67987	—
Reactant	4-nitro-1H-pyrrole-2-carboxylic Acid	HCID 7016560	—
Reactant	4-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-1h-pyrrole-2-carboxylic acid	HCID 57671144	—
Product	3-{[(2r)-2-({[6-(5-Chloro-2-methoxybenzyl)-3,7-dioxo-1,4-diazepan-1-yl]carbonyl}amino)butanoyl]amino}-4-fluorobenzoic acid	HCID 57671002	—

Reaction Steps

Instead of the starting material compound of Example 262, that is, 4-nitropyrrole-2-carboxylic acid, 4-fluoro-3-nitrobenzoic acid was used for the similar procedure as in Example 262 to obtain the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08049006B2
Source dataset	uspto-grants-2011_11
ORD ID	ord-2eb8e3a7198644e09ba810a0e9b160a2
Source note	uspto-grants-2011_11