反应详情

温度

0 °C

Mix 2-(4-chloro-phenyl)-4-(2,2-dimethoxy-ethyl)-thiazole-5-carboxylic acid methyl ester (3.6 g, 10.5 mmol) in EtOH (40 mL) and then add 2 M NaOH (6.8 mL). Stir the slurry mechanically overnight and then concentrate in vacuo. Dissolve the solid in water (40 mL), cool to 0° C., and adjust the pH to 5-6 with 1 N HCl (13 mL). Stir the slurry for 15 min, collect the precipitate, and wash the solid with water (4×20 mL). Dry the solid in a vacuum oven overnight to give 3.3 g (96%) of the title compound. ES/MS m/z (35Cl) 326.0 [M−1]−.

1. concentrationconcentrate in vacuo
2. dissolutionDissolve the solid in water (40 mL)
3. stirringStir the slurry for 15 min
4. customcollect the precipitate
5. washwash the solid with water (4×20 mL)
6. customDry the solid in a vacuum oven overnight