HCID 67463891, compound → HCID 67459150, compound

Participants

Reaction Steps

Dissolve 3-{2-methoxy-4-[4-oxo-2-(4-trifluoromethyl-phenyl)-4H-thiazolo[5,4-c]pyridin-5-yl]-phenoxy}-azetidine-1-carboxylic acid tert-butyl ester (1.3 g, 2.27 mmol) in dichloromethane (12 mL) and slowly add trifluoroacetic acid (6 mL). Stir the mixture for one hour and then evaporate. Apply the residue to a 10 g SCX column with dichloromethane. Wash the column with methanol then elute the material using 1:1 dichloromethane:2N ammonia/methanol. Concentrate to give 0.909 g (85%) of the desired product as a white solid. MS/ES m/z 474.0 [M+1]+.

Provenance & Evidence