Ethyl 2-(3-(2-(4-fluorobenzylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate → 4-Methyl-2-(2-oxo-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)imidazolidin-1-yl)thiazole-5-carboxylic acid

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Following the procedure as described in Preparation 9, making variations as required to replace ethyl 2-(3-(2-(4-fluorobenzylamino)-2-oxoethyl)-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate with ethyl 4-methyl-2-(2-oxo-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)imidazolidin-1-yl)thiazole-5-carboxylate, the crude title compound was obtained as a colorless solid in 85% yield: 1H NMR (300 MHz, DMSO-d6) δ 12.84 (br s, 1H), 4.09-4.00 (m, 4H), 3.84 (s, 2H), 3.65-3.57 (m, 2H), 3.42 (t, J=6.7 Hz, 2H), 3.30 (t, J=6.7 Hz, 2H), 2.51 (s, 3H), 1.95-1.84 (m, 2H), 1.83-1.71 (m, 2H); MS (ES+) m/z 339.3 (M+1).

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