Lithium hydroxide, monohydrate → HCID 57919906, compound

Participants

Reaction Steps

A suspension of 2-(3-(4-fluorobenzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)-4-methylthiazole-5-carboxylate in a mixture of tetrahydrofuran and water (2/1) is added lithium hydroxide monohydrate (6.9 equivalents) at ambient temperature. The reaction mixture is stirred at ambient temperature for 17 h and concentrated in vacuo. The residue is acidified by the addition of 4 M hydrochloric acid solution to pH ˜3. The solid is collected by filtration, washed with water and hexane, and dried in vacuo to afford the title compound.

Provenance & Evidence