1-Bromo-2-methylpropane → Ethyl 2-(3-isobutyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylate

HRID 554909Notes

Reaction equation

HRID 554909 reaction equation
BrCC1CC1(F)F.Br[CH2:9][CH:10]([CH3:12])[CH3:11].[CH3:13][C:14]1[N:15]=[C:16]([N:24]2[CH2:28][CH2:27][NH:26][C:25]2=[O:29])[S:17][C:18]=1[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH2:9]([N:26]1[CH2:27][CH2:28][N:24]([C:16]2[S:17][C:18]([C:19]([O:21][CH2:22][CH3:23])=[O:20])=[C:14]([CH3:13])[N:15]=2)[C:25]1=[O:29])[CH:10]([CH3:12])[CH3:11]

Participants

4

Reactant 3

HCID 65551-Bromo-2-methylpropaneHCID 27614022-(Bromomethyl)-1,1-difluorocyclopropaneHCID 57919776Ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate

Product 1

HCID 57919846Ethyl 2-(3-isobutyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylateYield 98%

Procedure

Following the procedure as described in Preparation 13, making variations to replace bromomethyl-2,2-difluorocyclopropane with 1-bromo-2-methylpropane to react with ethyl 4-methyl-2-(2-oxoimidazolidin-1-yl)thiazole-5-carboxylate, the title compound was obtained in 98% yield: MS (ES+) m/z 311.8 (M+1).

Workup

  1. customas described in Preparation 13

Sources & evidence

ORD record
ord-2003e8dd69314c96b8e80528d67bb8fd
Source dataset
uspto-grants-2011_11
Patent number
US08049016B2

Reaction notes

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