反应详情

温度

60 °C

100 ml of concentrated sulfuric acid were added to 25.0 g of 2-amino-5-bromopyridine, and 8.9 ml of concentrated nitric acid were then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour. The mixture was then stirred at 60° C. for 30 minutes. At the end of this time, the reaction mixture was poured into ice-water and neutralized by the addition of an aqueous solution of sodium hydroxide. The crystals which precipitated were collected by filtration and washed with ethanol, to give 19.1 g of the title compound, melting at 180°-182° C.

1. additionwere then added dropwise to the mixture at a temperature of 50° to 60° C. over a period of 1 hour
2. customThe crystals which precipitated
3. filtrationwere collected by filtration
4. washwashed with ethanol