HCID 11377493, compound → HCID 11296996, compound

Participants

Reaction Steps

Turbostatins 1 and 2 were obtained in the following order: Turbostatin 1 (10.1 mg) at 20.5 minutes and turbostatin 2 (11.2 mg) at 25.1 minutes. A103-mg fraction with ED50 0.56 μg/mL was separated on a semipreparative reversed-phase HPLC Zorbax SB C18 column with 85:15 CH3OH—H2O (a flow rate of 4 mL/min and the UV detector set at 208 nm). The result was that turbostatin 3 and turbostatin 4 were obtained in the following order: turbostatin 3 at 23.7 minutes and turbostatin 4 (8.3 mg) at 28.5 minutes.

Provenance & Evidence