HCID 178424903, compound → HCID 178465153, compound

HRID 555227Notes

Reaction equation

HRID 555227 reaction equation
CC1C(C)=C(C(C2N=CNC=2)C)C=CC=1.[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:58]=[CH:59][C:60]([OH:63])=[CH:61][CH:62]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20].CC(O)=O>O>[CH3:16][CH2:17][NH:18][C:19]([C@H:21]1[N:25]([C:26]([C@@H:28]([NH:36][C:37]([C@@H:39]([NH:44][C:45]([C@H:47]([NH:52][C:53]([C@@H:55]([NH:64][C:65]([C@@H:67]([NH:70][C:71]([C@@H:73]([NH:84][C:85]([C@@H:87]([NH:94][C:95]([C@H:97]2[NH:102][C:100](=[O:101])[CH2:99][CH2:98]2)=[O:96])[CH2:88][C:89]2[N:93]=[CH:92][NH:91][CH:90]=2)=[O:86])[CH2:74][C:75]2[C:79]3[CH:80]=[CH:81][CH:82]=[CH:83][C:78]=3[NH:77][CH:76]=2)=[O:72])[CH2:68][OH:69])=[O:66])[CH2:56][C:57]2[CH:62]=[CH:61][C:60]([OH:63])=[CH:59][CH:58]=2)=[O:54])[CH2:48][CH:49]([CH3:51])[CH3:50])=[O:46])[CH2:40][CH:41]([CH3:43])[CH3:42])=[O:38])[CH2:29][CH2:30][CH2:31][NH:32][C:33]([NH2:35])=[NH:34])=[O:27])[CH2:24][CH2:23][CH2:22]1)=[O:20]

Participants

4

Reactant 2

HCID 178424903HCID 178424903, compoundHCID 178476396HCID 178476396, compound

Product 1

HCID 178465153HCID 178465153, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Beagle dogs (10-15 Kg) were sedated with medetomidine (80 μg/kg) and an endoscope was inserted via the mouth, oesophagus and stomach into the duodenum. The test solutions (10 ml), comprising leuprolide acetate (Mallinckrodt Inc, St. Louis, Mo.) with or without enhancer reconstituted in deionised water were administered intraduodenally via the endoscope. Following removal of the endoscope, sedation was reversed using atipamezole (400 μg/kg). The parenteral reference solutions comprising 1 mg Leuprolide reconstituted in 0.5 ml sterile water were administered intravenously and subcutaneously respectively.

Workup

  1. customremoval of the endoscope, sedation

Sources & evidence

ORD record
ord-074707ea44794283a5014b6ce0496f18
Source dataset
uspto-grants-2011_11
Patent number
US08053429B2

Reaction notes

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