反应详情

A procedure similar to that described in Preparation 66 was repeated, except that 15 g of 2-chloro-3-nitropyridine, 13.22 g of aniline and 25.07 g of sodium carbonate were reacted in 180 ml of toluene. After working up the product as described in preparation 66, the resulting crude product was purified by column chromatography through silica gel, using a 1:5 by volume mixture of ethyl acetate and hexane, to give 6.9 g of the title compound, melting at 66°-68° C.

1. customA procedure similar to that described in Preparation 66
2. customas described in preparation 66
3. customthe resulting crude product was purified by column chromatography through silica gel
4. additionby volume mixture of ethyl acetate and hexane