HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzaldehyde → HCID 43338295, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | 5-Bromo-1,2,3-trimethoxybenzene | HCID 75885 | — |
| Reactant | Cornforth reagent | HCID 2724130 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Product | HCID 43338295 | HCID 43338295 | — |
Reaction Steps
First, magnesium was added to 1-bromo-3,4,5-trimethoxybenzene as a starting material, as shown in Reaction 6, and then 4-bromobenzaldehyde was added thereto to obtain a compound. Thus obtained compound was oxidized using PDC to obtain a Compound 21 derivative [(4-bromophenyl)(3,4,5-trimethoxyphenyl)methanone]. Using thus obtained compound as a starting material aminothiazole was introduced in the same manner as in the synthesis of Compound 516 to obtain Compound 571 in a form of a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053439B2 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-1862126e9fed49229808938514d23508 |
| Source note | uspto-grants-2011_11 |