Sodium Methoxide → HCID 57949209, compound

HRID 555255Notes

Reaction equation

HRID 555255 reaction equation
F[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH3:13])[S:11][CH:12]=2)=[CH:4][C:3]=1[C:14]([C:16]1[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=1)=[O:15].[CH3:28][O-:29].[Na+]>CO>[CH3:28][O:29][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:9]=[C:10]([CH3:13])[S:11][CH:12]=2)=[CH:4][C:3]=1[C:14]([C:16]1[CH:21]=[C:20]([O:22][CH3:23])[C:19]([O:24][CH3:25])=[C:18]([O:26][CH3:27])[CH:17]=1)=[O:15]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 66987527HCID 66987527, compound

Product 1

HCID 57949209HCID 57949209, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

(2-Fluoro-5-(2-methylthiazol-4-yl)phenyl)(3,4,5-trimethoxyphenyl)methanone (50 mg, 0.13 mmol) as a synthetic intermediate of Compound 596 was dissolved in NaOMe (2 ml) and methanol (5 ml). The solution was heat refluxed for 3 hours. After completion of the reaction, the reaction solution was extracted with water and dichloromethane, and the organic layer was vacuum concentrated.

Workup

  1. temperatureThe solution was heat
  2. temperaturerefluxed for 3 hours
  3. customAfter completion of the reaction
  4. extractionthe reaction solution was extracted with water and dichloromethane
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-9cf0ee44c98043aabcb66b068281839e
Source dataset
uspto-grants-2011_11
Patent number
US08053439B2

Reaction notes

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