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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 555304Generated: October 30, 2026

tert-Butyl piperazine-1-carboxylate → (S)-1-Boc-4-(oxiran-2-ylmethyl)piperazine

https://huagongshe.com/reaction/555304

Reaction equation

Participants

RoleNameHCIDCharge
Reactanttert-Butyl piperazine-1-carboxylateHCID 143452—
ReactantBenzenesulfonic acid, 3-nitro-, (2R)-2-oxiranylmethyl esterHCID 146513—
Product(S)-1-Boc-4-(oxiran-2-ylmethyl)piperazineHCID 1097762670%

Reaction Steps

The same method as employed in the preparation of Intermediate 1 but starting from piperazine-1-carboxylic acid tert-butyl ester and (R)-(−)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 70% yield.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08053436B1
Source datasetuspto-grants-2011_11
ORD IDord-41f78fbc52514ee69b8ce663b3f928ed
Source noteuspto-grants-2011_11