HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl piperazine-1-carboxylate → Tert-butyl 4-[[(2R)-oxiran-2-yl]methyl]piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl piperazine-1-carboxylate | HCID 143452 | — |
| Reactant | Benzenesulfonic acid, 3-nitro-, (2S)-2-oxiranylmethyl ester | HCID 146490 | — |
| Product | Tert-butyl 4-[[(2R)-oxiran-2-yl]methyl]piperazine-1-carboxylate | HCID 11010131 | 68% |
Reaction Steps
The same method as employed in the preparation of Intermediate 1 but starting from piperazine-1-carboxylic acid tert-butyl ester and (S)-(+)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 68% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08053436B1 |
| Source dataset | uspto-grants-2011_11 |
| ORD ID | ord-195a2ac33a4e4652901c5ac1a503e7e6 |
| Source note | uspto-grants-2011_11 |